S100P Interacts with p53 while Pentamidine Inhibits This Interaction
نویسندگان
چکیده
منابع مشابه
SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells.
Septins are a family of conserved cytoskeletal GTPase forming heteropolymeric filamentous structure in interphase cells, however, the mechanism of assembly are largely unknown. Here we described the characterization of SEPT12, sharing closest homology to SEPT3 and SEPT9. It was revealed that subcellular localization of SEPT12 varied at interphase and mitotic phase. While SEPT12 formed filamento...
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The MDMX oncoprotein is an important regulator of tumor suppressor p53 activity during embryonic development. Despite sequence homology to the ubiquitin E3 ligase MDM2, MDMX depletion activates p53 without significant increase in p53 level, implicating a degradation-independent mechanism. We present evidence that MDMX inhibits the sequence-specific DNA binding activity of p53. This function req...
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Pentamidine inhibits in vitro splicing of nuclear group I introns from rRNA genes of some pathogenic fungi and is known to inhibit mitochondrial function in yeast. Here we report that pentamidine inhibits the self-splicing of three group I and two group II introns of yeast mitochondria. Comparison of yeast strains with different configurations of mitochondrial introns (12, 5, 4, or 0 introns) r...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2021
ISSN: 2218-273X
DOI: 10.3390/biom11050634